pentobarbital will decrease the extent or influence of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will lessen the level or influence of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will decrease the extent or outcome of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers will not be proposed

pentobarbital will minimize the level or impact of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.

If this drug is employed for the duration of pregnancy, or Should the affected individual will become Expecting whilst taking this drug, the patient should be apprised of your probable hazard on the fetus

Contraindicated (one)pentobarbital will reduce the extent or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

Keep away from; coadministration with CYP3A inducers may perhaps cause diminished plasma concentrations of elvitegravir and/or possibly a concomitantly administered protease inhibitor and result in lack of therapeutic impact also to feasible resistance

pentobarbital will minimize the level or effect of nelfinavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

pentobarbital will lower the level or effect of docetaxel by influencing hepatic/intestinal enzyme CYP3A4 read more metabolism. Small/Significance Not known.

Remark: Barbiturates may perhaps maximize adverse effects, including respiratory depression, made by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.

pentobarbital will lower the extent or result of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

pentobarbital will reduce the extent or effect of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Reasonable CYP3A4 inducers might lessen progestin focus; take into account usage of extra barrier procedures

pentobarbital will minimize the level or impact of darifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will minimize the extent or outcome of zaleplon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.